gene

GPR165

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This page aggregates everything SciDEX knows about GPR165: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GPR165

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🧬 Gene Info

Gene Symbol	GPR165
Protein Type	Receptor
Function	GPR165 is classified as an adhesion GPCR (ADGR), a family of receptors characterized by extended N-terminal extracellular regions that mediate cell-cell and cell-matrix interactions.
Primary Expression	excitatory neurons, with lower expression in inhibitory interneurons and minimal glial expression [@striatal2020]
Ensembl ID	ENSG00000178209
GeneCards	GPR165
Human Protein Atlas	GPR165
[Tau](/proteins/tau) Pathology	Given its role in neuronal signaling, GPR165 may intersect with tau phosphorylation pathways, though direct evidence is lacking.
Therapeutic Target Potential	The receptor's restricted expression pattern and G protein coupling make it a potential target for modulating neuronal survival pathways in AD [@rnaseq2022].
Amyotrophic Lateral Sclerosis (ALS)	RNA-seq studies of spinal cord tissue from ALS patients have identified GPR165 expression changes, though the functional significance is unclear [@dopaminergic2021].
Huntington's Disease	Bioinformatic analyses have suggested potential dysregulation of GPR165 in Huntington's disease models, particularly in striatal neurons [@als2022].
Developmental Expression	High expression during embryonic and early postnatal development, particularly in the ventricular zone and cortical plate, suggesting roles in neurogenesis and migration [@tang2015].
Cell-Type Specificity	Expressed primarily in excitatory neurons, with lower expression in inhibitory interneurons and minimal glial expression [@striatal2020].
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

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Canonical Page

GPR165

gene · 880 words

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Pathway Diagram

graph TD
    GPR165["GPR165"]
    neurodegeneration["neurodegeneration"]
    GPR165 -->|"implicated_in"| neurodegeneration
    style GPR165 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

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Experiments (0)

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Related Papers (0)

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Related Research

Hypotheses and analyses mentioning GPR165 in their description or question text

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