Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR78: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GPR78 |
| Protein Type | Receptor |
| Function | GPR78 (GPRC5B) is a member of the G protein-coupled receptor, class C, group 5, member B. |
| Primary Expression | the brain and involved in synaptic transmission and neuronal development[@kroger2011] |
| Subcellular Localization | synapses and dendritic processes |
| Pathways | MAPK pathway, PI3K |
| Ensembl ID | ENSG00000137737 |
| GeneCards | GPR78 |
| Human Protein Atlas | GPR78 |
| Gα_i/o coupling | Primary G protein coupling inhibits adenylate cyclase |
| Gβγ signaling | Mediates downstream effectors through βγ subunits |
| ERK/MAPK pathway | Triggers cell proliferation and differentiation signals |
| PI3K/Akt pathway | Involved in cell survival and synaptic plasticity |
| Synaptic transmission | Modulates neurotransmitter release at presynaptic terminals |
| Dendritic spine formation | Regulates spine density and morphology |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GPR78["GPR78"]
neurodegeneration["neurodegeneration"]
GPR78 -->|"implicated_in"| neurodegeneration
style GPR78 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GPR78 in their description or question text
No additional research found