gene

GPX8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GPX8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

GPX8 — Glutathione Peroxidase 8

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🧬 Gene Info

Gene Symbol	GPX8
Full Name	Glutathione Peroxidase 8
Chromosome	5q31.2
Function	GPX8 exhibits several key functions
Primary Expression	Liver, Kidney, Brain, Intestine
UniProt ID	Q9D0M5
NCBI Gene ID	493869
Ensembl ID	ENSG00000164106
GeneCards	GPX8
Human Protein Atlas	GPX8
ER Oxidative Stress Defense	Reduces peroxides in the ER lumen, protecting against oxidative protein damage[@ramming2020]
UPR Regulation	Plays a role in modulating the PERK and IRE1α branches of the unfolded protein response[@chen2019]
Protein Folding	Maintains ER redox balance necessary for proper disulfide bond formation
Calcium Homeostasis	Helps regulate ER calcium storage through oxidative stress mitigation[@li2018]
Databases	GeneCards HPA STRING

🔮 Predicted Structure: GPX8 — AlphaFold Q9D0M5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GPX8 — Glutathione Peroxidase 8

gene · 545 words

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Pathway Diagram

graph TD
    GPX8["GPX8"]
    neurodegeneration["neurodegeneration"]
    GPX8 -->|"implicated_in"| neurodegeneration
    style GPX8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GPX8 in their description or question text

No additional research found