Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRINC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GRINC1 |
| Full Name | Glutamate Ionotropic Receptor NMDA Type Subunit 2C |
| Chromosome | 17q25.1 |
| Function | The GluN2C subunit forms functional NMDA receptors when assembled with the obligatory GluN1 subunit. |
| Primary Expression | Predominantly in cerebellar granule cells, olfactory bulb granule cells, thalamic relay neurons |
| UniProt ID | [Q9UQF2](https://www.uniprot.org/uniprot/Q9UQF2) |
| Ensembl ID | ENSG00000105409 |
| GeneCards | GRINC1 |
| Human Protein Atlas | GRINC1 |
| Biophysical properties | Moderate decay time, intermediate between GluN2A/B and GluN2D |
| Conductance | Lower single-channel conductance compared to GluN2A/B-containing receptors |
| Pharmacology | Sensitivity to ifenprodil (though less than GluN2B), selective agonists and antagonists |
| Epilepsy | Altered GRIN2C expression has been reported in some forms of epilepsy |
| Ataxia | Given its role in cerebellar function, GRIN2C may contribute to ataxic disorders |
| Schizophrenia | Some genetic association studies have suggested links to schizophrenia |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GRINC1["GRINC1"]
neurodegeneration["neurodegeneration"]
GRINC1 -->|"implicated_in"| neurodegeneration
style GRINC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GRINC1 in their description or question text
No additional research found