Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRIP3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GRIP3 is a PDZ domain-containing protein involved in synaptic organization and glutamate receptor trafficking. Key player in synaptic plasticity and neuronal signaling.
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| Gene Symbol | GRIP3 |
| Full Name | Glutamate Receptor Interacting Protein 3 |
| Chromosome | Xq28 |
| Protein Type | Scaffold Protein |
| Function | is a member of the GRIP family of PDZ domain-containing scaffold proteins that play critical roles in synaptic organization, glutamate receptor trafficking, and neuronal signaling. |
| Primary Expression | specific brain regions where it contributes to synaptic plasticity and neuronal function |
| Subcellular Localization | postsynaptic compartments, where it associates with excitatory synapses using glutamate as the neurotransmitter |
| Molecular Weight | 116 kDa |
| Amino Acids | 063 aa |
| UniProt ID | Q9N2L8 |
| NCBI Gene ID | 10054 |
| Ensembl ID | ENSG00000155906 |
| GeneCards | GRIP3 |
| Human Protein Atlas | GRIP3 |
| Ionotropic glutamate receptors | GRIP3 may influence NMDA receptor function indirectly through interactions with associated proteins |
| Associated Diseases | Alzheimer's Disease, Intellectual Disability, Neurodevelopmental Disorders |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GRIP3["GRIP3"]
neurodegeneration["neurodegeneration"]
GRIP3 -->|"implicated_in"| neurodegeneration
style GRIP3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning GRIP3 in their description or question text
No additional research found