protein

GRM6PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GRM6PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	GRM6PROTEIN
Protein Type	Receptor
Function	is an excellent target for gene therapy
Subcellular Localization	makes it invaluable for understanding retinal circuitry and has direct clinical
Molecular Weight	95 kDa
GeneCards	GRM6PROTEIN
Human Protein Atlas	GRM6PROTEIN
Venus Flytrap Domain (VFD)	Large extracellular N-terminal domain that binds glutamate with high affinity. The binding pocket has unique residues adapted for the retinal environment.
Cysteine-Rich Domain (CRD)	Connects the VFD to the transmembrane domain. This region shows structural features specific to mGluR6.
Seven-Transmembrane Domain (7TM)	The transmembrane region (TM1-TM7) that couples to Gi/o proteins. Critical for signal transduction in the bipolar cell.
C-terminal Tail	Intracellular domain with multiple phosphorylation sites, PDZ-binding motifs, and protein interaction domains.
Unique gating kinetics	Slower activation and deactivation compared to other mGluRs
Specific dimer interface	Distinct from other mGluR subtypes
Specialized allosteric binding sites	Different from brain mGluRs
Associated Diseases	Congenital Stationary Night Blindness, High Myopia
KG Connections	3 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR6 Protein (Metabotropic Glutamate Receptor 6)

protein · 1246 words

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Pathway Diagram

graph TD
    GRM6PROTEIN["GRM6PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRM6PROTEIN -->|"implicated_in"| neurodegeneration
    style GRM6PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning GRM6PROTEIN in their description or question text

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