| Gene Symbol | GRM6PROTEIN |
| Protein Type | Receptor |
| Function | is an excellent target for gene therapy |
| Subcellular Localization | makes it invaluable for understanding retinal circuitry and has direct clinical |
| Molecular Weight | 95 kDa |
| GeneCards | GRM6PROTEIN |
| Human Protein Atlas | GRM6PROTEIN |
| Venus Flytrap Domain (VFD) | Large extracellular N-terminal domain that binds glutamate with high affinity. The binding pocket has unique residues adapted for the retinal environment. |
| Cysteine-Rich Domain (CRD) | Connects the VFD to the transmembrane domain. This region shows structural features specific to mGluR6. |
| Seven-Transmembrane Domain (7TM) | The transmembrane region (TM1-TM7) that couples to Gi/o proteins. Critical for signal transduction in the bipolar cell. |
| C-terminal Tail | Intracellular domain with multiple phosphorylation sites, PDZ-binding motifs, and protein interaction domains. |
| Unique gating kinetics | Slower activation and deactivation compared to other mGluRs |
| Specific dimer interface | Distinct from other mGluR subtypes |
| Specialized allosteric binding sites | Different from brain mGluRs |
| Associated Diseases | Congenital Stationary Night Blindness, High Myopia |
| KG Connections | 3 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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