protein

GRM7PROTEIN

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GRM7PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	GRM7PROTEIN
Protein Type	Receptor
Function	is a Group III metabotropic glutamate receptor that serves as the primary presynaptic autoreceptor in the central nervous system.
Primary Expression	the basal ganglia - Regulates glutamate release in the striatum - Modulates indirect pathway activity - May influence levodopa-induced dyskinesias (LI
Subcellular Localization	</td><td>Presynaptic active zones, axon terminals</td></tr>
Molecular Weight	102 kDa
GeneCards	GRM7PROTEIN
Human Protein Atlas	GRM7PROTEIN
Venus Flytrap Domain (VFD)	Large extracellular N-terminal domain responsible for glutamate binding. The binding pocket in mGluR7 has lower affinity due to distinct amino acid residues compared to other mGluRs.
Cysteine-Rich Domain (CRD)	Connects the VFD to the transmembrane domain. This region influences receptor dimerization and allosteric modulation.
Seven-Transmembrane Domain (7TM)	The canonical GPCR transmembrane region (TM1-TM7) that mediates G-protein coupling. The intracellular loops are critical for downstream signaling.
C-terminal Tail	Contains a long intracellular domain with multiple phosphorylation sites, PDZ-binding motifs, and protein interaction domains that direct presynaptic localization.
High expression	Hippocampus (CA1-CA3, dentate gyrus), cortex (layers II-III), basal ganglia (striatum, globus pallidus), cerebellum
Cellular localization	Predominantly presynaptic on glutamatergic and GABAergic terminals
Subcellular localization	Enriched at the active zone, directly opposite the postsynaptic density
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR7 Protein (Metabotropic Glutamate Receptor 7)

protein · 1418 words

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Pathway Diagram

graph TD
    GRM7PROTEIN["GRM7PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRM7PROTEIN -->|"implicated_in"| neurodegeneration
    style GRM7PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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