| Gene Symbol | GRM7PROTEIN |
| Protein Type | Receptor |
| Function | is a Group III metabotropic glutamate receptor that serves as the primary presynaptic autoreceptor in the central nervous system. |
| Primary Expression | the basal ganglia - Regulates glutamate release in the striatum - Modulates indirect pathway activity - May influence levodopa-induced dyskinesias (LI |
| Subcellular Localization | </td><td>Presynaptic active zones, axon terminals</td></tr> |
| Molecular Weight | 102 kDa |
| GeneCards | GRM7PROTEIN |
| Human Protein Atlas | GRM7PROTEIN |
| Venus Flytrap Domain (VFD) | Large extracellular N-terminal domain responsible for glutamate binding. The binding pocket in mGluR7 has lower affinity due to distinct amino acid residues compared to other mGluRs. |
| Cysteine-Rich Domain (CRD) | Connects the VFD to the transmembrane domain. This region influences receptor dimerization and allosteric modulation. |
| Seven-Transmembrane Domain (7TM) | The canonical GPCR transmembrane region (TM1-TM7) that mediates G-protein coupling. The intracellular loops are critical for downstream signaling. |
| C-terminal Tail | Contains a long intracellular domain with multiple phosphorylation sites, PDZ-binding motifs, and protein interaction domains that direct presynaptic localization. |
| High expression | Hippocampus (CA1-CA3, dentate gyrus), cortex (layers II-III), basal ganglia (striatum, globus pallidus), cerebellum |
| Cellular localization | Predominantly presynaptic on glutamatergic and GABAergic terminals |
| Subcellular localization | Enriched at the active zone, directly opposite the postsynaptic density |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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