protein

GRM8PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GRM8PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Like other mGluRs, mGluR8 functions as an obligate homodimer.

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🔬 Protein Info

Gene Symbol	GRM8PROTEIN
Protein Type	Receptor
Function	is a Group III metabotropic glutamate receptor with the highest glutamate affinity among the presynaptic Group III receptors.
Subcellular Localization	and protein interactions
Molecular Weight	98 kDa
GeneCards	GRM8PROTEIN
Human Protein Atlas	GRM8PROTEIN
Venus Flytrap Domain (VFD)	The extracellular N-terminal domain that binds glutamate. mGluR8 has higher glutamate affinity compared to other Group III receptors due to distinct binding pocket architecture.
Cysteine-Rich Domain (CRD)	Connects the VFD to the transmembrane domain. This domain influences receptor activation and allosteric modulation.
Seven-Transmembrane Domain (7TM)	The transmembrane region (TM1-TM7) that couples to Gi/o proteins. Contains allosteric binding sites for modulators.
C-terminal Tail	Intracellular domain with phosphorylation sites and PDZ-binding motifs that direct subcellular localization and protein interactions.
Highest expression	Olfactory bulb, cerebral cortex (layers II-III), hippocampus (CA1)
Moderate expression	Basal ganglia (striatum, globus pallidus), thalamus, amygdala, cerebellum
Cellular localization	Predominantly presynaptic on glutamatergic terminals
Subcellular localization	Active zones, perisynaptic regions
Associated Diseases	Als
KG Connections	15 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

mGluR8 Protein (Metabotropic Glutamate Receptor 8)

protein · 1429 words

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Pathway Diagram

graph TD
    GRM8PROTEIN["GRM8PROTEIN"]
    neurodegeneration["neurodegeneration"]
    GRM8PROTEIN -->|"implicated_in"| neurodegeneration
    style GRM8PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning GRM8PROTEIN in their description or question text

No additional research found