| Gene Symbol | GRM8PROTEIN |
| Protein Type | Receptor |
| Function | is a Group III metabotropic glutamate receptor with the highest glutamate affinity among the presynaptic Group III receptors. |
| Subcellular Localization | and protein interactions |
| Molecular Weight | 98 kDa |
| GeneCards | GRM8PROTEIN |
| Human Protein Atlas | GRM8PROTEIN |
| Venus Flytrap Domain (VFD) | The extracellular N-terminal domain that binds glutamate. mGluR8 has higher glutamate affinity compared to other Group III receptors due to distinct binding pocket architecture. |
| Cysteine-Rich Domain (CRD) | Connects the VFD to the transmembrane domain. This domain influences receptor activation and allosteric modulation. |
| Seven-Transmembrane Domain (7TM) | The transmembrane region (TM1-TM7) that couples to Gi/o proteins. Contains allosteric binding sites for modulators. |
| C-terminal Tail | Intracellular domain with phosphorylation sites and PDZ-binding motifs that direct subcellular localization and protein interactions. |
| Highest expression | Olfactory bulb, cerebral cortex (layers II-III), hippocampus (CA1) |
| Moderate expression | Basal ganglia (striatum, globus pallidus), thalamus, amygdala, cerebellum |
| Cellular localization | Predominantly presynaptic on glutamatergic terminals |
| Subcellular localization | Active zones, perisynaptic regions |
| Associated Diseases | Als |
| KG Connections | 15 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
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