Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GTF2H3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | GTF2H3 |
| Full Name | General Transcription Factor IIH Subunit 3 |
| Chromosome | 12q24.31 |
| Function | is a critical regulatory subunit of the TFIIH complex that plays essential roles in both RNA polymerase II transcription and nucleotide excision repair (NER). |
| Primary Expression | all neuronal populations - Higher expression in metabolically active neurons - Localized to both nucleus and cytoplasm - Required for baseline transcr |
| Molecular Weight | 66 kDa |
| Amino Acids | 327 aa |
| UniProt ID | Q9Y5J0 |
| NCBI Gene ID | 2967 |
| Ensembl ID | ENSG00000156976 |
| OMIM | 601753 |
| GeneCards | GTF2H3 |
| Human Protein Atlas | GTF2H3 |
| Alternative Names | TFB3, MAT1, TFIIH subunit 3 |
| Module | Subunits |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GTF2H3["GTF2H3"]
neurodegeneration["neurodegeneration"]
GTF2H3 -->|"implicated_in"| neurodegeneration
style GTF2H3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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| Source | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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| No papers found | ||||