| Gene Symbol | GTF2H3 |
| Full Name | General Transcription Factor IIH Subunit 3 |
| Aliases | TFIIH subunit p34, TFB3, CAK subunit |
| Chromosome | 12q24.31 |
| Protein Family | TFIIH complex |
| Function | is a critical regulatory subunit of the TFIIH complex that plays essential roles in both RNA polymerase II transcription and nucleotide excision repair (NER). |
| Primary Expression | all neuronal populations
- Higher expression in metabolically active neurons
- Localized to both nucleus and cytoplasm
- Required for baseline transcr |
| Subcellular Localization | Nucleus (nuclear speckles, nucleoplasm) |
| Molecular Weight | ~66 kDa (573 amino acids) |
| Amino Acids | 327 aa |
| UniProt ID | Q9Y5J0 |
| NCBI Gene ID | 2967 |
| Ensembl ID | ENSG00000156976 |
| OMIM | 601753 |
| GeneCards | GTF2H3 |
| Human Protein Atlas | GTF2H3 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |