gene

GTF2H5

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about GTF2H5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🧬 Gene Info

Gene Symbol	GTF2H5
Full Name	General Transcription Factor IIH Subunit 5 (TTDA)
Chromosome	6q25.3
Protein Type	Transcription Factor
Function	encodes a small 71-amino acid subunit of the Transcription Factor IIH (TFIIH) complex that is essential for both transcription initiation and nucleotide excision repair (NER) [@gigliamari2004].
Molecular Weight	8 kDa
Amino Acids	71 aa
UniProt ID	[Q86WW5](https://www.uniprot.org/uniprot/Q86WW5)
Ensembl ID	ENSG00000167291
OMIM	607332
GeneCards	GTF2H5
Human Protein Atlas	GTF2H5
N-terminal domain	Involved in protein-protein interactions
Dimerization interface	Forms the functional homodimer
TFIIH interaction surface	Binds specifically to the TFIIH core complex
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

GTF2H5 — General Transcription Factor IIH Subunit 5 (TTDA)

gene · 2107 words

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Pathway Diagram

graph TD
    GTF2H5["GTF2H5"]
    neurodegeneration["neurodegeneration"]
    GTF2H5 -->|"implicated_in"| neurodegeneration
    style GTF2H5 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning GTF2H5 in their description or question text

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