gene

HERC1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HERC1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Hypotheses

0Analyses

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0Experiments

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Summary

Comprehensive review of HERC1 gene, E3 ubiquitin ligase, and its critical role in protein quality control, autophagy, and neurodegenerative diseases including Alzheimer's and Parkinson's

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🧬 Gene Info

Gene Symbol	HERC1
Full Name	HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 1
Chromosome	15q22.31
Protein Type	Ligase
Function	is a massive E3 ubiquitin ligase enzyme that plays critical roles in protein quality control, autophagy, DNA repair, and cellular signaling.
Subcellular Localization	2. HECT Domain (C-terminal)
Molecular Weight	532 kDa
Amino Acids	862 aa
Exons	54
Pathways	HERC1 Role
Ensembl ID	ENSG00000102786
GeneCards	HERC1
Human Protein Atlas	HERC1
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HERC1 — HECT and RLD Domain Containing E3 Ubiquitin Protein Ligase 1

gene · 1453 words

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Pathway Diagram

graph TD
    HERC1["HERC1"]
    neurodegeneration["neurodegeneration"]
    HERC1 -->|"implicated_in"| neurodegeneration
    style HERC1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HERC1 in their description or question text

No additional research found