Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HIF1α: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| h-a93292f54f | targeted_by | hypothesis | 1.00 |
| Glycolysis in pro-inflammatory macrophages | activates | mechanism | 0.90 |
| Aerobic Glycolysis | mediates | process | 0.85 |
| metabolic reprogramming | mediates | process | 0.80 |
| PUM1 | upregulates | gene | 0.80 |
| ERRα | inhibits | protein | 0.72 |
| glycolytic shift | activates | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| h-a93292f54f | targets | hypothesis | 1.00 |
| HV1 | regulates | gene | 0.85 |
| Hv1 | regulates | protein | 0.80 |
| ERRα | activates | protein | 0.64 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial Metabolic Trained Immunity via mTOR-HIF1α Axis | 0.644 | developmental-neurobiology | Do perinatal immune challenges create pe |
| Metabolic Rewiring via SPP1-Induced HIF1α Glycolytic Shift | 0.620 | neuroinflammation | What molecular mechanisms mediate SPP1-i |
| Dysregulated microglial glycolysis via HIF1α activation shif | 0.520 | neurodegeneration | Synaptic pruning by microglia in neurode |
| CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metab | 0.380 | developmental-neurobiology | Do perinatal immune challenges create pe |
| CCR2-Mediated Microglial Replacement Drives mTOR-HIF1α Metab | 0.351 | developmental-neurobiology | Do perinatal immune challenges create pe |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-11 | 0 hypotheses
developmental neurobiology | 2026-04-07 | 13 hypotheses Top: 0.649
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| mTOR Signaling Pathway Regulates the Release of Proinflammatory Molecule CCL5 Im [PMID:35422816] | Unknown | Front Immunol | 2022 | 0 |
| Monocytic Infiltrates Contribute to Autistic-like Behaviors in a Two-Hit Model o [PMID:33127853] | Unknown | J Neurosci | 2020 | 0 |
| Focal brain inflammation and autism. [PMID:23570274] | Unknown | J Neuroinflammation | 2013 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.71 · 2026-04-21
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
Hypotheses and analyses mentioning HIF1α in their description or question text
No additional research found