concept

HV1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HV1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

41Outgoing

12Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	HV1
Key Genes/Proteins	HIF1α, HIF1A
Related Diseases	Cognitive Impairments, cognitive impairment
Related Pathways	NF-κB, NF-κB Signaling Pathway

Pathway Diagram

graph TD
    HV1["HV1"]
    HV1 -.protects against.-> Lipopolysaccharide_Induced_Neu["Lipopolysaccharide-Induced Neuroinflammation"]
    HV1 -.protects against.-> Neuroinflammation["Neuroinflammation"]
    HV1 -->|"modulates"| NF__B_Signaling_Pathway["NF-kappaB Signaling Pathway"]
    HV1 -->|"involved_in"| Microglial_Activation["Microglial Activation"]
    HV1 -->|"regulates"| HIF1_["HIF1alpha"]
    HV1 -->|"risk_factor_for"| Cognitive_Impairments["Cognitive Impairments"]
    GENES["GENES"] -->|"inhibits"| HV1
    PFKFB3["PFKFB3"] -->|"inhibits"| HV1
    PI3K["PI3K"] -->|"regulates"| HV1
    MICROGLIA["MICROGLIA"] -->|"regulates"| HV1
    NEUROINFLAMMATION["NEUROINFLAMMATION"] -->|"regulates"| HV1
    AKT["AKT"] -->|"regulates"| HV1
    INFLAMMATION["INFLAMMATION"] -->|"regulates"| HV1
    NF__B["NF-KappaB"] -->|"regulates"| HV1

Outgoing (43)

Target	Relation	Type	Str
Lipopolysaccharide-Induced Neuroinflammation	protects_against	process	0.95
Neuroinflammation	protects_against	process	0.95
NF-κB	activates	pathway	0.95
NF-κB Signaling Pathway	modulates	pathway	0.90
NF-κB Signaling Pathway	regulates	pathway	0.90
Microglial Activation	involved_in	process	0.90
HIF1α	regulates	protein	0.85
Microglial Activation	contributes_to	process	0.85
Cognitive Impairments	risk_factor_for	disease	0.85
Microglial Activation	regulates	process	0.85
HIF1A	upregulates	gene	0.85
microglial activation	promotes	process	0.85
neuroinflammation	promotes	process	0.80
MICROGLIAL	expressed_in	cell_type	0.80
cognitive impairment	contributes_to	phenotype	0.80
cognitive impairment	therapeutic_target	phenotype	0.80
Ms	associated_with	disease	0.65
Neuroinflammation	regulates	disease	0.65
Inflammation	regulates	disease	0.65
AND	regulates	gene	0.60
HK2	inhibits	gene	0.60
NF-ΚB	regulates	gene	0.60
AKT	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
Glycolysis	inhibits	pathway	0.60
Akt	regulates	pathway	0.60
Nf-Κb	regulates	pathway	0.60
Pi3K	regulates	pathway	0.60
PI3K	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
Neuroinflammatory	contributes_to	pathway	0.60
Pi3K/Akt	regulates	pathway	0.60
Microglia	regulates	cell_type	0.60
RNA	regulates	gene	0.60
GENES	inhibits	gene	0.60
HIF1	regulates	gene	0.60
PFKFB3	inhibits	gene	0.60
Cytokine	regulates	protein	0.60
Ras	associated_with	protein	0.60
Microglia	expressed_in	cell_type	0.55

Incoming (12)

Source	Relation	Type	Str
GENES	inhibits	gene	0.60
PFKFB3	inhibits	gene	0.60
PI3K	regulates	gene	0.60
MICROGLIA	regulates	gene	0.60
NEUROINFLAMMATION	regulates	gene	0.60
AKT	regulates	gene	0.60
INFLAMMATION	regulates	gene	0.60
NF-ΚB	regulates	gene	0.60
HK2	inhibits	gene	0.60
RNA	regulates	gene	0.60
AND	regulates	gene	0.60
HIF1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found