protein

HIP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HIP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for HIP2 (Huntingtin Interacting Protein 2)

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🔬 Protein Info

Gene Symbol	HIP2
Aliases	Huntingtin Interacting Protein 2
Protein Type	Enzyme
Function	The FIC domain catalyzes the transfer of AMP from ATP to target proteins (AMPylation), a reversible post-translational modification that regulates chaperone function.
Subcellular Localization	</strong> Endoplasmic reticulum lumen</li> <li><strong>PDB:</strong> [6BG1](http
Molecular Weight	52 kDa
GeneCards	HIP2
Human Protein Atlas	HIP2
N-terminal ER-targeting signal sequence	directs the protein to the ER lumen
Transmembrane domain	anchors the protein to the ER membrane with the catalytic domain in the ER lumen
TPR-like domain	mediates protein-protein interactions
Huntingtin binding	HIP2 binds to the N-terminal region of huntingtin
Proteasome regulation	HIP2 also interacts with the 26S proteasome, potentially linking HD pathology to impaired protein degradation
ER stress in HD	Expanded huntingtin causes ER stress, and HIP2 dysfunction may exacerbate this
Alzheimer's disease	Chronic ER stress contributes to Aβ toxicity and tau pathology
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HIP2 (Huntingtin Interacting Protein 2)

protein · 738 words

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Pathway Diagram

graph TD
    HIP2["HIP2"]
    neurodegeneration["neurodegeneration"]
    HIP2 -->|"implicated_in"| neurodegeneration
    style HIP2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HIP2 in their description or question text

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