protein

HNRNPC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HNRNPC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

2Outgoing

0Incoming

Summary

Page for HNRNPC Protein

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🔬 Protein Info

Gene Symbol	HNRNPC
Function	HNRNPC contains two RNA recognition motifs (RRMs) in the central and C-terminal regions, connected by an acidic linker region. The protein forms a heterotetramer with HNRNPC-like proteins (HNRNPL).
Subcellular Localization	Nucleus, nucleolus Protein Family:** hnRNP C family ## Structure HNRNPC c
Molecular Weight	59 kDa
GeneCards	HNRNPC
Human Protein Atlas	HNRNPC
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    HNRNPC["HNRNPC Protein"]
    TDP43["TDP-43 Protein"]
    CES["Cryptic Exon Splicing"]
    HNRNPC_Gene["HNRNPC Gene"]
    Pre_mRNA["Pre-mRNA Substrates"]
    Splicing_Complex["Spliceosome Complex"]
    Aberrant_Transcripts["Aberrant mRNA Transcripts"]
    NMD["Nonsense-Mediated Decay"]
    Protein_Aggregates["Protein Aggregates"]
    ALS["Amyotrophic Lateral Sclerosis"]
    FTD["Frontotemporal Dementia"]
    Nuclear_Transport["Nuclear Transport Dysfunction"]
    RNA_Granules["Stress Granules"]
    Motor_Neurons["Motor Neuron Death"]
    Synaptic_Function["Synaptic Dysfunction"]

    HNRNPC_Gene -->|"transcribes"| HNRNPC
    HNRNPC -->|"regulates"| TDP43
    HNRNPC -->|"modulates"| CES
    HNRNPC -->|"binds"| Pre_mRNA
    HNRNPC -->|"recruits"| Splicing_Complex
    CES -->|"produces"| Aberrant_Transcripts
    Aberrant_Transcripts -->|"triggers"| NMD
    TDP43 -->|"forms"| Protein_Aggregates
    TDP43 -->|"impairs"| Nuclear_Transport
    TDP43 -->|"accumulates in"| RNA_Granules
    Protein_Aggregates -->|"causes"| ALS
    Protein_Aggregates -->|"causes"| FTD
    Nuclear_Transport -->|"leads to"| Motor_Neurons
    RNA_Granules -->|"disrupts"| Synaptic_Function

    style HNRNPC fill:#1a3a4a,stroke:#4fc3f7
    style NMD fill:#1a3a2a,stroke:#81c784
    style Splicing_Complex fill:#1a3a2a,stroke:#81c784
    style CES fill:#3a1a1a,stroke:#ef5350
    style Protein_Aggregates fill:#3a1a1a,stroke:#ef5350
    style Nuclear_Transport fill:#3a1a1a,stroke:#ef5350
    style HNRNPC_Gene fill:#2a1a3a,stroke:#ce93d8
    style TDP43 fill:#2a1a3a,stroke:#ce93d8
    style ALS fill:#3a2a1a,stroke:#ffa726
    style FTD fill:#3a2a1a,stroke:#ffa726

Outgoing (2)

Target	Relation	Type	Str
TDP-43	regulates	protein	0.80
Cryptic Exon Splicing	modulates	process	0.75

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HNRNPC

Understanding Entity Pages

Summary

Wiki Pages (5)

RNA Metabolism Dysregulation in Alzheimer's Disease

hnrnpm

VIRMA (KIAA1429)