gene

HOXA1

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HOXA1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for HOXA1 Gene

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🧬 Gene Info

Gene Symbol	HOXA1
Chromosome	7p15.2
Protein Family	Homeobox family, HoxA cluster
Protein Type	Transcription Factor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	neural stem cells of the subventricular zone - Neuronal Plasticity: May regulate experience-dependent gene expression - Circuit Maintenance: I
Subcellular Localization	Nucleus
Molecular Weight	37.3 kDa
Amino Acids	355 aa
Pathways	Modulates Wnt, BMP, and FGF signaling
UniProt ID	[P49639](https://www.uniprot.org/uniprot/P49639)
GeneCards	HOXA1
Human Protein Atlas	HOXA1
Homeodomain	A 60-amino acid DNA-binding helix-turn-helix motif
N-terminal transactivation domain	Rich in acidic residues
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

HOXA1 Gene

gene · 907 words

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Homeobox A1 Protein (HOXA1)

protein · 878 words

→

Pathway Diagram

graph TD
    HOXA1["HOXA1"]
    neurodegeneration["neurodegeneration"]
    HOXA1 -->|"implicated_in"| neurodegeneration
    style HOXA1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HOXA1 in their description or question text

No additional research found