gene

HPN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HPN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Comprehensive gene profile of HPN (hepsin) in neurodegenerative diseases including Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	HPN
Full Name	Hepsin
Chromosome	19q13.12
Protein Type	Protease
Function	encodes a 419-amino acid serine protease that is expressed in multiple tissues including liver, kidney, prostate, and brain.
Primary Expression	multiple tissues including liver, kidney, prostate, and brain
Subcellular Localization	the cell surface where it participates in extracellular matrix remodeling, growth factor activation, and protease cascad
Amino Acids	419 aa
Exons	6
Pathways	NF-κB
UniProt ID	[P05981](https://www.uniprot.org/uniprot/P05981)
Ensembl ID	ENSG00000105855
GeneCards	HPN
Human Protein Atlas	HPN
Gene length	~7.5 kb
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HPN — Hepsin

gene · 1782 words

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Pathway Diagram

flowchart TD
    A["Upstream Regulators"] --> B["HPN"]
    B --> C["Molecular Mechanism"]
    C --> D["Cellular Effects"]
    D --> E["Pathological Consequences"]

Outgoing (0)

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No outgoing edges

Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HPN in their description or question text

No additional research found