gene

HRH4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HRH4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

HRH4 Gene

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🧬 Gene Info

Gene Symbol	HRH4
Full Name	Histamine Receptor H4
Chromosome	18p11.21
Function	HRH4 encodes the H4 histamine receptor.
Primary Expression	the brain and play roles in cognitive function, attention, and motor control
UniProt ID	[Q9Y5N2](https://www.uniprot.org/uniprotkb/Q9Y5N2/entry)
GeneCards	HRH4
Human Protein Atlas	HRH4
HRH1, HRH2, HRH3 Genes	Other histamine receptor family members with distinct pharmacology and neural functions
Histamine	Primary ligand for H4 receptor signaling
Microglia	Primary H4-expressing brain cells involved in neuroinflammation
NF-κB Pathway	Key transcription factor cascade downstream of H4 signaling
Neuroinflammation	Central process mediating H4 receptor contribution to neurodegeneration
Associated Diseases	Inflammation, allergy
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HRH4 Gene

gene · 620 words

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Pathway Diagram

graph TD
    HRH4["HRH4"]
    neurodegeneration["neurodegeneration"]
    HRH4 -->|"implicated_in"| neurodegeneration
    style HRH4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning HRH4 in their description or question text

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