protein

HSP22PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HSP22PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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0Analyses

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Summary

Hsp22 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	HSP22PROTEIN
Full Name	Hsp22 / HspB8
Protein Type	Chaperone
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	Muscle, neurons, heart, spinal cord
Molecular Weight	24 kDa
UniProt ID	Q9UQ16
GeneCards	HSP22PROTEIN
Human Protein Atlas	HSP22PROTEIN
α-Crystallin Domain	The C-terminal α-crystallin domain mediates oligomerization and substrate binding
HSP70/HSP90 Complex	HspB8 cooperates with HSP70 and HSP90 to facilitate protein folding and clearance
Selective Autophagy	HspB8 helps target aggregation-prone proteins to the autophagy-lysosomal system
Stress Response	Upregulated under cellular stress conditions including heat shock, oxidative stress, and proteotoxic stress
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: HSP22PROTEIN — AlphaFold Q9UQ16 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Hsp22 Protein

protein · 744 words

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Pathway Diagram

graph TD
    HSP22PROTEIN["HSP22PROTEIN"]
    neurodegeneration["neurodegeneration"]
    HSP22PROTEIN -->|"implicated_in"| neurodegeneration
    style HSP22PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HSP22PROTEIN in their description or question text

No additional research found