| Gene Symbol | HSP22PROTEIN |
| Full Name | Hsp22 / HspB8 |
| Protein Type | Chaperone |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | Muscle, neurons, heart, spinal cord |
| Molecular Weight | 24 kDa |
| UniProt ID | Q9UQ16 |
| GeneCards | HSP22PROTEIN |
| Human Protein Atlas | HSP22PROTEIN |
| α-Crystallin Domain | The C-terminal α-crystallin domain mediates oligomerization and substrate binding |
| HSP70/HSP90 Complex | HspB8 cooperates with HSP70 and HSP90 to facilitate protein folding and clearance |
| Selective Autophagy | HspB8 helps target aggregation-prone proteins to the autophagy-lysosomal system |
| Stress Response | Upregulated under cellular stress conditions including heat shock, oxidative stress, and proteotoxic stress |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
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