gene

HSPB10

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about HSPB10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for HSPB10 Gene

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🧬 Gene Info

Gene Symbol	HSPB10
Function	is a gene that encodes a protein belonging to the small heat shock protein family.
Molecular Weight	30 kDa
Amino Acids	341 aa
Ensembl ID	ENSG00000147133
GeneCards	HSPB10
Human Protein Atlas	HSPB10
Sperm Outer Dense Fibers	The protein is a major component of the outer dense fibers (ODFs) of the sperm flagellum, which are essential for protecting the sperm axoneme during transit through the female reproductive tract [2]
Male Fertility	ODF1 is crucial for normal sperm motility and male fertility; mutations can cause asthenozoospermia (reduced sperm motility) [3]
Chaperone Activity	Like other sHSPs, HSPB10 may function as a molecular chaperone, preventing protein aggregation under stress conditions [4]
Testis	Highest expression in testis, specifically in spermatids during spermiogenesis
Sperm	Present in the sperm flagellum as a structural component
Other Tissues	Very low or undetectable expression in most somatic tissues, including brain
Protein Quality Control	sHSPs prevent aggregation of misfolded proteins
Stress Response	Upregulated under cellular stress conditions
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HSPB10 Gene

gene · 877 words

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Pathway Diagram

graph TD
    HSPB10["HSPB10"]
    neurodegeneration["neurodegeneration"]
    HSPB10 -->|"implicated_in"| neurodegeneration
    style HSPB10 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning HSPB10 in their description or question text

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