Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HSPBAP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Comprehensive review of HSPBAP1 gene, a small heat shock protein-associated protein with potential roles in neurodegeneration and protein homeostasis
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| Gene Symbol | HSPBAP1 |
| Full Name | HSPB Associated Protein 1 |
| Chromosome | 4q21 |
| Function | is a human gene located on chromosome 4q21 that encodes a protein implicated in the small heat shock protein (sHsp) family network. |
| Primary Expression | Cortex, Hippocampus, Cerebellum, Spinal cord |
| Molecular Weight | 50 kDa |
| Amino Acids | 466 aa |
| UniProt ID | Q9N2I8 |
| NCBI Gene ID | 79668 |
| Ensembl ID | ENSG00000125821 |
| OMIM | 610092 |
| GeneCards | HSPBAP1 |
| Human Protein Atlas | HSPBAP1 |
| Chaperone network amplification | By binding to multiple sHsp family members, HSPBAP1 may extend the substrate scope of the chaperone network |
| Complex formation | HSPBAP1 may serve as a scaffold for assembling multi-sHsp complexes with enhanced protective function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HSPBAP1["HSPBAP1"]
neurodegeneration["neurodegeneration"]
HSPBAP1 -->|"implicated_in"| neurodegeneration
style HSPBAP1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HSPBAP1 in their description or question text
No additional research found