protein

HTR1BPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR1BPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Htr1B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	HTR1BPROTEIN
Protein Type	Receptor
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	** \| Plasma membrane, presynaptic terminals \|
Molecular Weight	50 kDa
GeneCards	HTR1BPROTEIN
Human Protein Atlas	HTR1BPROTEIN
N-terminal extracellular domain	Contains glycosylation sites
Transmembrane helices (TM1-TM7)	Form the ligand-binding pocket
Cysteine-rich disulfide bond	Between ECL1 and ECL2 for structural stability
Differential splicing	Generates multiple receptor isoforms
Presynaptic autoreceptor	Located on serotonin neuron terminals, inhibits further 5-HT release
Presynaptic heteroreceptor	Modulates glutamate, GABA, and dopamine release
Migraine pathophysiology	Trigeminovascular activation involves HTR1B
Aggression and mood	Prefrontal cortex expression affects aggressive behavior
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

htr1b Protein

protein · 572 words

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Pathway Diagram

graph TD
    HTR1BPROTEIN["HTR1BPROTEIN"]
    neurodegeneration["neurodegeneration"]
    HTR1BPROTEIN -->|"implicated_in"| neurodegeneration
    style HTR1BPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTR1BPROTEIN in their description or question text

No additional research found