Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HTR2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | HTR2B |
| Chromosome | 2q36.3 |
| Protein Type | Receptor |
| Function | The serotonin 2B receptor (5-HT2B) is a G protein-coupled receptor that primarily couples to Gq proteins, activating phospholipase C and leading to increased intracellular calcium. |
| Primary Expression | the cortex, hippocampus, and basal ganglia |
| Amino Acids | 481 aa |
| Exons | 13 |
| Ensembl ID | ENSG00000180264 |
| GeneCards | HTR2B |
| Human Protein Atlas | HTR2B |
| N-terminal extracellular domain | Contains glycosylation sites |
| Seven transmembrane domains (TM1-TM7) | Form the ligand-binding pocket |
| Third intracellular loop | Contains the Gq protein coupling domain |
| C-terminal intracellular tail | Contains serine/threonine residues for phosphorylation and β-arrestin recruitment |
| Cerebral cortex | Pyramidal neurons in layers II-VI |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
HTR2B["HTR2B"]
neurodegeneration["neurodegeneration"]
HTR2B -->|"implicated_in"| neurodegeneration
style HTR2B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning HTR2B in their description or question text
No additional research found