Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HTR5A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Gene encoding the 5-HT5A serotonin receptor, a G protein-coupled receptor involved in neuronal signaling, sleep regulation, and cognitive function.
| Gene Symbol | HTR5A |
| Chromosome | 7q36.3 |
| Protein Type | G protein-coupled receptor, Family 5-HT |
| Function | is a seven-transmembrane domain GPCR that couples primarily to Gα<sub>i/o</sub> proteins, leading to inhibition of adenylate cyclase and reduced cyclic AMP (cAMP) production. |
| Subcellular Localization | - **Cerebral cortex**: Particularly layer V pyramidal neurons |
| Pathways | MAPK Pathway, PI3K |
| UniProt ID | P30939 |
| NCBI Gene ID | 3363 |
| GeneCards | HTR5A |
| Human Protein Atlas | HTR5A |
| Official Full Name | 5-hydroxytryptamine receptor 5A |
| Protein Class | G protein-coupled receptor, Family 5-HT |
| Drug Class | Examples |
| Agonists | LSD, 5-CT |
| Antagonists | SB-699929, AS-203 |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
HTR5A["HTR5A"]
neurodegeneration["neurodegeneration"]
HTR5A -->|"implicated_in"| neurodegeneration
style HTR5A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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