HTR7

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Page for htr7 Gene

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graph TD
    HTR7["HTR7 (5-HT7 Receptor)"]
    
    Serotonin["Serotonin (5-HT)"]
    cAMP["cAMP"]
    PKA["Protein Kinase A"]
    CREB["CREB"]
    BDNF["BDNF"]
    Neuroplasticity["Neuroplasticity"]
    
    Depression["Depression"]
    Stress["Chronic Stress"]
    Cortisol["Cortisol"]
    
    Neuroinflammation["Neuroinflammation"]
    Microglia["Activated Microglia"]
    Cytokines["Pro-inflammatory Cytokines"]
    
    Apoptosis["Neuronal Apoptosis"]
    Neurodegeneration["Neurodegeneration"]
    
    Serotonin -->|"binds"| HTR7
    HTR7 -->|"activates"| cAMP
    cAMP -->|"activates"| PKA
    PKA -->|"phosphorylates"| CREB
    CREB -->|"transcribes"| BDNF
    BDNF -->|"promotes"| Neuroplasticity
    
    HTR7 -->|"associated_with"| Depression
    Depression -->|"correlates_with"| Stress
    Stress -->|"elevates"| Cortisol
    Cortisol -->|"promotes"| Neuroinflammation
    
    Neuroinflammation -->|"activates"| Microglia
    Microglia -->|"releases"| Cytokines
    Cytokines -->|"induces"| Apoptosis
    Apoptosis -->|"leads_to"| Neurodegeneration
    
    style HTR7 fill:#1a3a4a,stroke:#4fc3f7
    style BDNF fill:#1a3a2a,stroke:#81c784
    style Neuroplasticity fill:#1a3a2a,stroke:#81c784
    style CREB fill:#2a1a3a,stroke:#ce93d8
    style PKA fill:#2a1a3a,stroke:#ce93d8
    style Depression fill:#3a2a1a,stroke:#ffa726
    style Neurodegeneration fill:#3a2a1a,stroke:#ffa726
    style Neuroinflammation fill:#3a1a1a,stroke:#ef5350
    style Apoptosis fill:#3a1a1a,stroke:#ef5350
    style Cytokines fill:#3a1a1a,stroke:#ef5350