disease

depression

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about depression: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

4928Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

depression is a disease characterized by neurodegeneration research. Key relationships include: associated with, treats, protects against. Associated with Alzheimer's disease. Connected to 30 entities in the SciDEX knowledge graph.

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Disease Info

Prevalence	~280 million people worldwide
Associated Genes	BDNF, AKT, ABIN1, HTR7, NLRP3, IL6, TLR4, ADRA2A
Therapeutic Agents	phytochemicals, C1q neutralizing antibody, antidepressants, PCS-1, Hyperibone J, probiotics
KG Connections	365 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

flowchart TD
    DEPRESSION(["DEPRESSION"])
    Alzheimer["Alzheimer"]
    Depression["Depression"]
    Anxiety["Anxiety"]
    Inflammation["Inflammation"]
    Parkinson["Parkinson"]
    Als["Als"]

    DEPRESSION -->|"associated with"| Alzheimer
    DEPRESSION -->|"associated with"| Depression
    DEPRESSION -->|"associated with"| Anxiety
    DEPRESSION -.->|"inhibits"| Depression
    DEPRESSION -->|"regulates"| Depression
    DEPRESSION -->|"contributes to"| Depression
    DEPRESSION -->|"activates"| Inflammation
    DEPRESSION -->|"associated with"| Parkinson
    DEPRESSION -->|"activates"| Depression
    DEPRESSION -->|"associated with"| Inflammation
    DEPRESSION -->|"associated with"| Als
    DEPRESSION -->|"interacts with"| Depression
    DEPRESSION -->|"therapeutic target"| Als
    DEPRESSION -->|"activates"| Als
    DEPRESSION -->|"therapeutic target"| Depression

    style DEPRESSION fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (2248)

Target	Relation	Type	Str
prefrontal cortex	affects	brain_region	0.90
serotonin	disrupts	neurotransmitter	0.90
NMDA receptor	involves	receptor	0.90
synaptic plasticity	involves	pathway	0.90
microglia	affects	cell_type	0.90
neurons	affects	cell_type	0.90
hippocampus	affects	brain_region	0.90
unfolded protein response	involves	pathway	0.90
astrocytes	affects	cell_type	0.90
cortex	affects	brain_region	0.90
neural stem cells	affects	cell_type	0.90
thalamus	affects	brain_region	0.80
hypothalamus	affects	brain_region	0.80
amygdala	affects	brain_region	0.80
JAK-STAT signaling	involves	pathway	0.80
glaucoma	risk_factor_for	disease	0.75
amyloid-β	associated_with	protein	0.70
tau	associated_with	protein	0.70
BDNF	associated_with	protein	0.70
dysbiosis	associated_with	process	0.70
striatum	affects	brain_region	0.70
oxytocin	disrupts	neurotransmitter	0.70
purinergic receptor	involves	receptor	0.70
neuropeptide Y	disrupts	neurotransmitter	0.70
nicotinic receptor	involves	receptor	0.70
nucleus accumbens	affects	brain_region	0.70
norepinephrine	disrupts	neurotransmitter	0.70
serotonin receptor	involves	receptor	0.70
dopamine receptor	involves	receptor	0.70
BDNF-TrkB signaling	involves	pathway	0.70
ferroptosis	involves	pathway	0.70
Alzheimer's disease	associated_with	disease	0.70
pyroptosis	involves	pathway	0.70
PI3K-AKT-mTOR signaling	involves	pathway	0.70
epigenetic regulation	involves	pathway	0.70
NF-kB signaling	involves	pathway	0.70
autophagy pathway	involves	pathway	0.70
MAPK signaling	involves	pathway	0.70
oxidative stress response	involves	pathway	0.70
retinal ganglion cell degeneration	promotes	process	0.65
regenerative medicine	associated_with	process	0.60
complement cascade	involves	pathway	0.60
locus coeruleus	affects	brain_region	0.60
insulin signaling	involves	pathway	0.60
cerebellum	affects	brain_region	0.60
GABA-B receptor	involves	receptor	0.60
temporal lobe	affects	brain_region	0.60
muscarinic receptor	involves	receptor	0.60
adenosine receptor	involves	receptor	0.60
adenosine	disrupts	neurotransmitter	0.60

Incoming (2680)

Source	Relation	Type	Str
dysbiosis	associated_with	phenotype	0.95
repetitive transcranial magnetic stimulation	treats	process	0.95
rTMS	treats	drug	0.95
ACOT12	risk_factor_for	gene	0.92
lipopolysaccharide	causes	drug	0.90
PPARGC1A	protects_against	gene	0.90
Bifidobacterium breve	treats	organism	0.90
Hyperibone J	treats	drug	0.90
dysbiosis	promotes	phenotype	0.90
neurotransmitter systems	regulates	pathway	0.90
stress	risk_factor_for	process	0.90
dorsolateral prefrontal cortex	therapeutic_target	brain_region	0.90
glutamatergic neurotransmission	associated_with	process	0.90
GABAergic neurotransmission	associated_with	process	0.90
RIPK1	promotes	protein	0.90
neuroinflammation	causes	process	0.90
ketamine	treats	compound	0.90
PI3K/AKT	therapeutic_target	pathway	0.90
inflammation	promotes	process	0.90
ventral hippocampus to medial prefrontal cortex circuit	regulates	pathway	0.88
gut microbiota metabolites	regulates	process	0.88
LSD	treats	drug	0.88
ventral hippocampus	associated_with	brain_region	0.86
PI3K/AKT pathway	modulates	pathway	0.85
PACAP	protects_against	protein	0.85
NLRP3	associated_with	gene	0.85
PARKIN	protects_against	gene	0.85
EGFR	therapeutic_target	protein	0.85
indole-3-lactic acid	prevents	protein	0.85
neuroinflammation	promotes	process	0.85
ADK	risk_factor_for	protein	0.85
trigeminal neuralgia	causes	disease	0.85
gut microbiota	associated_with	process	0.85
gut-brain axis	modulates	pathway	0.85
HPA axis	dysregulation_associated_with	pathway	0.85
inflammatory mediators	promotes	process	0.85
glutamatergic system	therapeutic_target	pathway	0.85
monoaminergic neurotransmission	associated_with	process	0.85
RIPK1 inhibition	treats	process	0.85
genetics	risk_factor_for	process	0.85
TLR4	associated_with	protein	0.82
excitatory synaptic transmission	promotes	process	0.82
C1q neutralizing antibody	treats	drug	0.80
PI3K	associated_with	pathway	0.80
PI3K	therapeutic_target	gene	0.80
BDNF	protects_against	protein	0.80
gut microbiota dysbiosis	risk_factor_for	phenotype	0.80
estrogen deficiency	risk_factor_for	phenotype	0.80
accelerated scheduling	modulates	process	0.80
BDNF	regulates	gene	0.80

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

depression

Understanding Entity Pages

Summary

Wiki Pages (21)

Depression in Neurodegeneration

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Clinical Management Guide for CBS/PSP

Progressive Supranuclear Palsy (PSP)

Parkinson's Disease

Sleep and Circadian Dysfunction in Alzheimer's Disease

primary-progressive-aphasia

Atypical Parkinsonism

Device Therapies Comparison for CBS/PSP

CBS/PSP Rehabilitation Master Guide

calcium-dysregulation-comparison

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

nimodipine-als

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Treatment Rankings