Ibudilast

Understanding Entity Pages

This page aggregates everything SciDEX knows about Ibudilast: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

<div class="infobox infobox-treatment">

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flowchart TD
    Ibudilast["Ibudilast"] -->|"references"| NLRP3["NLRP3"]
    FINGOLIMOD["FINGOLIMOD"] -->|"associated with"| IBUDILAST["IBUDILAST"]
    Fingolimod["Fingolimod"] -->|"treats"| Ischemic_Brain_Injury["Ischemic Brain Injury"]
    Fingolimod["Fingolimod"] -.->|"inhibits"| HMGB1_TLR4_NF__B_Signaling_Pat["HMGB1/TLR4/NF-kappaB Signaling Pathway"]
    Fingolimod["Fingolimod"] -.->|"downregulates"| IL_1_["IL-1beta"]
    Fingolimod["Fingolimod"] -.->|"downregulates"| IL_6["IL-6"]
    NLRP3["NLRP3"] -->|"associated with"| Inflammation["Inflammation"]
    NLRP3["NLRP3"] -->|"activates"| Inflammasome["Inflammasome"]
    NLRP3["NLRP3"] -.->|"inhibits"| Inflammation["Inflammation"]
    NLRP3["NLRP3"] -.->|"inhibits"| Als["Als"]
    style Ibudilast fill:#6d3000,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0
    style NLRP3 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style FINGOLIMOD fill:#6d3000,stroke:#333,color:#e0e0e0
    style IBUDILAST fill:#6d3000,stroke:#333,color:#e0e0e0
    style Fingolimod fill:#6d3000,stroke:#333,color:#e0e0e0
    style Ischemic_Brain_Injury fill:#ef5350,stroke:#333,color:#e0e0e0
    style HMGB1_TLR4_NF__B_Signaling_Pat fill:#1b5e20,stroke:#333,color:#e0e0e0
    style IL_1_ fill:#006494,stroke:#333,color:#e0e0e0
    style IL_6 fill:#006494,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammasome fill:#1b5e20,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0