concept

FINGOLIMOD

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FINGOLIMOD: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

60Connections

0Hypotheses

0Analyses

39Outgoing

21Incoming

0Experiments

0Debates

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Pathway Diagram

graph TD
    FINGOLIMOD["FINGOLIMOD"]
    FINGOLIMOD -->|"treats"| Ischemic_Brain_Injury["Ischemic Brain Injury"]
    FINGOLIMOD -->|"inhibits"| HMGB1_TLR4_NF__B_Signaling_Pat["HMGB1/TLR4/NF-kappaB Signaling Pathway"]
    FINGOLIMOD -->|"downregulates"| IL_1_["IL-1beta"]
    FINGOLIMOD -->|"downregulates"| IL_6["IL-6"]
    FINGOLIMOD -->|"downregulates"| TNF__["TNF-alpha"]
    FINGOLIMOD -->|"inhibits"| S1P_RECEPTOR["S1P RECEPTOR"]
    FINGOLIMOD -->|"inhibits"| T_Cell_Infiltration["T Cell Infiltration"]
    FINGOLIMOD -->|"treats"| Neuroinflammation["Neuroinflammation"]
    Bezafibrate["Bezafibrate"] -->|"interacts"| FINGOLIMOD
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"] -->|"inhibits"| FINGOLIMOD
    CD4["CD4"] -->|"inhibits"| FINGOLIMOD
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"metabolizes"| FINGOLIMOD

Outgoing (39)

Target	Relation	Type	Str
Ischemic Brain Injury	treats	disease	0.95
HMGB1/TLR4/NF-κB Signaling Pathway	inhibits	pathway	0.92
IL-6	downregulates	protein	0.92
TNF-α	downregulates	protein	0.92
IL-1β	downregulates	protein	0.92
S1P RECEPTOR	inhibits	receptor	0.90
T Cell Infiltration	inhibits	process	0.85
CD4 T Cell Infiltration	inhibits	process	0.85
Neuroinflammation	treats	process	0.85
H2-Ea Upregulation	associated_with	process	0.80
CERAMIDE	encodes	phenotype	0.65
MICROGLIA	targets	cell_type	0.65
NLRP3 INFLAMMASOME	inhibits	pathway	0.65
NLRP3	inhibits	gene	0.65
MICROGLIA	inhibits	cell_type	0.65
STING	treats	gene	0.65
BDNF	causes	gene	0.65
STING	inhibits	gene	0.65
CD4	associated_with	gene	0.60
Alzheimer's disease	treats	disease	0.60
unfolded protein response	modulates	pathway	0.60
CERS2	activates	gene	0.60
CERS2	regulates	gene	0.60
SGMS1	associated_with	gene	0.60
NEUROINFLAMMATION	inhibits	phenotype	0.56
PD1	associated_with	gene	0.50
IBUDILAST	associated_with	drug	0.45
ALZHEIMER	associated_with	disease	0.45
NEURONS	associated_with	cell_type	0.45
BDNF	associated_with	gene	0.45
STRIATUM	associated_with	brain_region	0.45
CERAMIDE	associated_with	phenotype	0.45
TREM2	associated_with	gene	0.45
NLRP3	associated_with	gene	0.45
MICROGLIA	associated_with	cell_type	0.45
ASTROCYTE	associated_with	cell_type	0.45
NEURON	inhibits	cell_type	0.35
MICROGLIA	therapeutic_target	cell_type	0.35
HIPPOCAMPUS	activates	brain_region	0.35

Incoming (21)

Source	Relation	Type	Str
Bezafibrate	interacts_with	drug	0.80
NLRP3 INFLAMMASOME	activates	pathway	0.65
NLRP3	treats	gene	0.65
HUNTINGTON	enhances	gene	0.50
MULTIPLE SCLEROSIS	associated_with	disease	0.45
ALZHEIMER	associated_with	disease	0.45
CERAMIDE	associated_with	phenotype	0.45
DIMETHYL FUMARATE	associated_with	drug	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
INFLAMMATION	associated_with	phenotype	0.45
METABOLIC REPROGRAMMING	associated_with	phenotype	0.45
TRAUMATIC BRAIN INJURY	associated_with	disease	0.45
SPHINGOMYELIN	associated_with	phenotype	0.45
NLRP3 INFLAMMASOME	associated_with	pathway	0.45
MINOCYCLINE	associated_with	drug	0.45
AMYOTROPHIC LATERAL SCLEROSIS	associated_with	disease	0.45
ALZHEIMER'S DISEASE	associated_with	disease	0.45
ALPHA-SYNUCLEIN	inhibits	gene	0.35
CD4	inhibits	gene	0.35
ALZHEIMER'S DISEASE	metabolizes	disease	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity