gene

IFT172

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This page aggregates everything SciDEX knows about IFT172: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for IFT172 — Intraflagellar Transport Protein 172

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🧬 Gene Info

Gene Symbol	IFT172
Full Name	Intraflagellar Transport Protein 172
Chromosome	2
Function	Intraflagellar Transport Protein 172 (IFT172) is a core component of the IFT-B complex (Intraflagellar Transport complex B) that is essential for cilia and flagella assembly, maintenance, and function
Primary Expression	photoreceptor outer segments, where it transports opsin and other visual pigments
Pathways	Wnt
Ensembl ID	ENSG00000124608
GeneCards	IFT172
Human Protein Atlas	IFT172
Ciliogenesis	IFT172 is required for the formation and maintenance of primary cilia, which serve as signaling centers for hedgehog (Shh), Wnt, and PDGF signaling pathways[@tayeh2022]
Intraflagellar transport	As part of IFT-B, IFT172 mediates anterograde transport (from basal body to ciliary tip) along microtubules
Hedgehog signaling	Primary cilia are essential for hedgehog signal transduction; IFT172 mutations disrupt Shh pathway activity
photoreceptor maintenance	IFT172 is highly expressed in photoreceptor outer segments, where it transports opsin and other visual pigments
Neuronal cilia function	Primary cilia on neurons regulate neurogenesis and signaling
Axonal growth	IFT proteins regulate microtubule dynamics in growing axons[@letteboer2021]
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IFT172 — Intraflagellar Transport Protein 172

gene · 562 words

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Genes

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Pathway Diagram

graph TD
    IFT172["IFT172"]
    neurodegeneration["neurodegeneration"]
    IFT172 -->|"implicated_in"| neurodegeneration
    style IFT172 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
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