Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IKKALPHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | IKKALPHA |
| Protein Type | Protein |
| Function | is a cytoplasmic inhibitory protein that functions as a critical negative regulator of the nuclear factor-kappa B (NF-κB) signaling pathway. |
| Molecular Weight | 36 kDa |
| Pathways | NF-κB |
| UniProt ID | Search UniProt |
| GeneCards | IKKALPHA |
| Human Protein Atlas | IKKALPHA |
| Ankyrin Repeat Domain | Six tandem ankyrin repeats (residues 1-183) constitute the primary NF-κB binding interface, providing high-affinity interaction with NF-κB p65/p50 heterodimers[^2] |
| Signal-Responsive Domain (SRD) | Located at the N-terminus (residues 1-70), this region contains two conserved serine residues (Ser32 and Ser36) that are phosphorylation targets for the IκB kinase (IKK) complex |
| Nuclear Localization Signals (NLS) | Enable IκBα to enter the nucleus and bind to NF-κB already present in nuclear compartments[^3] |
| Degron Sequences | Phosphorylation-dependent ubiquitination sites that target IκBα for 26S proteasomal degradation following IKK-mediated phosphorylation |
| C-Terminal PEST Domain | Rich in proline, glutamic acid, serine, and threonine residues; contributes to protein instability and rapid turnover[^4] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IKKALPHA["IKKALPHA"]
neurodegeneration["neurodegeneration"]
IKKALPHA -->|"implicated_in"| neurodegeneration
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning IKKALPHA in their description or question text
No additional research found