Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ITGB3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ITGB3 |
| Aliases | Integrin Beta-3 |
| Function | Integrin Beta-3 (ITGB3, also known as CD61) is a transmembrane receptor that pairs with ITGAV (αV) to form the αVβ3 integrin (Vitronectin receptor). |
| Molecular Weight | 91 kDa |
| Pathways | NF-κB |
| GeneCards | ITGB3 |
| Human Protein Atlas | ITGB3 |
| KG Connections | 2 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ITGB3["ITGB3"]
FGF2["FGF2"]
FGF2 -->|"binds"| ITGB3
style ITGB3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| FGF2 | binds | protein | 0.95 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SPP1 | binds_to | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neuroinflammation | 2026-04-15 | 13 hypotheses Top: 0.752
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
Hypotheses and analyses mentioning ITGB3 in their description or question text
No additional research found