Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNA6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Page for KCNA6 Protein (Potassium Voltage-Gated Channel Subfamily A Member 6)
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| Gene Symbol | KCNA6 |
| Aliases | Potassium Voltage-Gated Channel Subfamily A Member 6 |
| Protein Type | Gene |
| Function | encodes a six-transmembrane (S1–S6) voltage-gated potassium channel alpha subunit with the canonical pore-loop selectivity filter between S5 and S6. |
| Molecular Weight | 60 kDa |
| GeneCards | KCNA6 |
| Human Protein Atlas | KCNA6 |
| Tetramerization competence | Kv1.6 can co-assemble with other Kv1 subunits, altering activation/inactivation kinetics versus homomeric channels.[@chandy1995][@jan2012] |
| Delayed-rectifier behavior | Supports action-potential repolarization and limits repetitive burst firing in excitable cells.[@chandy1995][@long2005] |
| Subcellular targeting logic | Kv-family channels are differentially targeted to soma, dendrites, axons, and presynaptic compartments through motif-dependent trafficking and scaffold interactions.[@chandy1995][@misonou2004] |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KCNA6["KCNA6"]
neurodegeneration["neurodegeneration"]
KCNA6 -->|"implicated_in"| neurodegeneration
style KCNA6 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
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Experimental studies targeting or related to this entity
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KCNA6 in their description or question text
No additional research found