protein

KCNC3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNC3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Kv3.3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	KCNC3PROTEIN
Full Name	Kv3.3
Protein Family	Voltage-gated potassium channels (Kv3 subfamily)
Protein Type	Channel
Function	is an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight	~95 kDa
UniProt ID	Q9UK33
GeneCards	KCNC3PROTEIN
Human Protein Atlas	KCNC3PROTEIN
6 transmembrane segments (S1-S6)	S1-S4 form the voltage-sensing domain, while S5-S6 comprise the pore domain
Voltage sensor (S4)	Contains positively charged residues that respond to membrane depolarization
Pore region (S5-S6)	Forms the ion conduction pathway with high selectivity for K+ ions
Cytoplasmic N- and C-termini	Contain regulatory domains and binding sites for intracellular signaling molecules
Tetrameric assembly	Forms functional channels as tetramers of α subunits
Associated Diseases	neurodegeneration
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: KCNC3PROTEIN — AlphaFold Q9UK33 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Kv3.3 Protein

protein · 827 words

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Pathway Diagram

graph TD
    KCNC3PROTEIN["KCNC3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    KCNC3PROTEIN -->|"implicated_in"| neurodegeneration
    style KCNC3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCNC3PROTEIN in their description or question text

No additional research found