protein

KCND3PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCND3PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Kv4.3 Potassium Channel Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.

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🔬 Protein Info

Gene Symbol	KCND3PROTEIN
Protein Type	Channel
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	</th><td>Plasma Membrane (Dendrites)</td></tr>
Amino Acids	4477 aa
GeneCards	KCND3PROTEIN
Human Protein Atlas	KCND3PROTEIN
S1-S6 segments	Six transmembrane α-helices
S4 voltage sensor	Positively charged residues detect membrane potential
P-loop (H5)	Forms the ion selectivity filter
S6 C-terminus	Forms the inner pore gate
N-terminal T1 domain	TetramERization domain, mediates auxiliary subunit interaction
KChIP binding site	Intracellular N-terminal binding for KChIP proteins
DPP6/DPP10 binding	C-terminal interaction for trafficking modulation
CaMKII phosphorylation	Enhances current, reduces inactivation
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Kv4.3 Potassium Channel Protein

protein · 784 words

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Pathway Diagram

graph TD
    KCND3PROTEIN["KCND3PROTEIN"]
    neurodegeneration["neurodegeneration"]
    KCND3PROTEIN -->|"implicated_in"| neurodegeneration
    style KCND3PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning KCND3PROTEIN in their description or question text

No additional research found