Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNJ1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KCNJ1 |
| Full Name | Potassium Inwardly Rectifying Channel Subfamily J Member 1 |
| Aliases | Page for KCNJ1 Gene, ROMK Potassium Channel |
| Chromosome | 21q22.1 |
| Function | ### Renal Physiology |
| Primary Expression | renal epithelial cells [1] |
| Molecular Weight | 38 kDa |
| Amino Acids | 391 aa |
| UniProt ID | P48048 |
| NCBI Gene ID | 3766 |
| Ensembl ID | ENSG00000151704 |
| OMIM | 170359 |
| GeneCards | KCNJ1 |
| Human Protein Atlas | KCNJ1 |
| Two transmembrane domains (M1 and M2) | Form the pore structure |
| Associated Diseases | Renal Tubular Hypokalemic Alkalosis, Bartter Syndrome, Alzheimer's Disease, Parkinson's Disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNJ1["KCNJ1"]
neurodegeneration["neurodegeneration"]
KCNJ1 -->|"implicated_in"| neurodegeneration
style KCNJ1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KCNJ1 in their description or question text
No additional research found