Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNJ8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KCNJ8 |
| Full Name | KCNJ8 - Potassium Voltage-Gated Channel Subfamily J Member 8 |
| Chromosome | 12p12.1 |
| Protein Family | Inward-rectifier potassium channel family (Kir6.x) |
| Protein Type | Channel |
| Function | KCNJ8 encodes Kir6.1, the pore-forming subunit of the ATP-sensitive potassium channel (KATP channel) |
| Subcellular Localization | Plasma membrane (neurons, cardiac myocytes, smooth muscle) |
| Molecular Weight | 48 kDa |
| UniProt ID | Q15818 |
| Ensembl ID | ENSG00000130159 |
| GeneCards | KCNJ8 |
| Human Protein Atlas | KCNJ8 |
| Transmembrane Domains | Two transmembrane helices (M1 and M2) that span the neuronal membrane, creating the channel pore |
| Pore Helix (H5/P-loop) | Located between M1 and M2, contains the K+ selectivity filter with the characteristic GYG motif essential for K+ selectivity |
| N-terminus | Cytoplasmic domain containing the PIP2 binding site and ATP binding region |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KCNJ8["KCNJ8"]
neurodegeneration["neurodegeneration"]
KCNJ8 -->|"implicated_in"| neurodegeneration
style KCNJ8 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KCNJ8 in their description or question text
No additional research found