gene

KCNMB2

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KCNMB2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

KCNMB2

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🧬 Gene Info

Gene Symbol	KCNMB2
Full Name	Potassium calcium-activated channel subfamily M regulatory beta subunit 2
Chromosome	3q26.32
Function	The BK channel is encoded by KCNMA1 and requires association with beta subunits for proper function
Primary Expression	the central nervous system where they play critical roles in neuronal excitability, neurotransmitter release, and protection against excitotoxic cell
UniProt ID	Q9Y5W6
NCBI Gene ID	10242
Ensembl ID	ENSG00000171388
GeneCards	KCNMB2
Human Protein Atlas	KCNMB2
Beta-2 subunit function	Modulates channel gating kinetics, increases calcium sensitivity, and targets channels to specific subcellular compartments[@orio2002]
Tissue-specific regulation	Beta-2 subunit expression is enriched in brain and heart tissue
Channel properties	BK channels have exceptionally large conductance (100-250 pS) and are activated by both membrane depolarization and intracellular calcium
Action potential repolarization	Rapid repolarization contributes to high-frequency firing
Afterhyperpolarization	Modulates the afterhyperpolarization phase
Associated Diseases	neurodegeneration
Databases	GeneCards HPA STRING

🔮 Predicted Structure: KCNMB2 — AlphaFold Q9Y5W6 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNMB2

gene · 1372 words

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Pathway Diagram

graph TD
    KCNMB2["KCNMB2"]
    neurodegeneration["neurodegeneration"]
    KCNMB2 -->|"implicated_in"| neurodegeneration
    style KCNMB2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning KCNMB2 in their description or question text

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