gene

KCNMB4

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KCNMB4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

Page for KCNMB4

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🧬 Gene Info

Gene Symbol	KCNMB4
Protein Type	Channel
Function	KCNMB4 encodes a 210-amino acid auxiliary subunit that modulates BK channel (encoded by KCNMA1) function:
Primary Expression	inner ear hair cells
Subcellular Localization	mitochondria (mitoBK channels) and affect neuronal survival. beta4 subunit composition may influence this protective fun
Amino Acids	210 aa
Ensembl ID	ENSG00000135677
GeneCards	KCNMB4
Human Protein Atlas	KCNMB4
N-terminal Extracellular Domain	Mediates interactions with the extracellular matrix and other proteins [@jaffe2011].
Transmembrane Segment	Single transmembrane helix anchoring the subunit to the membrane.
C-terminal Intracellular Domain	Interacts with the cytoplasmic domain of the BK alpha-subunit to modulate gating [@jaffe2011].
Gating Kinetics	beta4 subunits accelerate activation and slow deactivation of BK channels [@wang2019].
Calcium Sensitivity	Modifies the calcium sensitivity of the channel, shifting the activation curve [@wang2019].
Voltage Dependence	Alters voltage dependence of activation [@latorre2006].
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

KCNMB4

gene · 1204 words

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Pathway Diagram

graph TD
    KCNMB4["KCNMB4"]
    neurodegeneration["neurodegeneration"]
    KCNMB4 -->|"implicated_in"| neurodegeneration
    style KCNMB4 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

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Related Research

Hypotheses and analyses mentioning KCNMB4 in their description or question text

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