Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KINASE ACTIVITY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TGM2 | mediates | protein | 0.90 |
| LRRK2-G2019S | upregulates | phenotype | 0.88 |
| LRRK2 | upregulates | protein | 0.85 |
| TGM2 | catalyzes | protein | 0.85 |
| LRRK2 | inhibits | gene | 0.80 |
| LRRK2 | regulates | protein | 0.70 |
| LRRK2 missense mutations | activates | gene | 0.70 |
| LRRK2 | involved_in | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| G2019S primarily raises baseline LRRK2 kinase activity rathe | 0.790 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
| Choline Kinase Activity as Membrane Integrity Response Indic | 0.663 | translational-neuroscience | Which metabolic biomarkers can distingui |
| LRRK2 G2019S Uncouples RAB29-Dependent Spatial Control from | 0.640 | neurodegeneration | Do pathogenic LRRK2 mutations amplify vo |
| Amyloid Plaque Clearance Triggers Downstream Reduction in Ta | 0.475 | - | Can CSF p-tau217 normalization serve as |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| LRRK2 kinase-mediated accumulation of lysosome-associated phospho-Rabs in tauopa [PMID:41128923] | Buck SA, Malankhanova T, Strader S, Ma E | Acta neuropathologica | 2025 | 0 |
| RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome hom [PMID:39343966] | Li X, Zhu H, Huang BT, Li X, Kim H, Tan | Nature communications | 2024 | 0 |
| Exploring the focal role of LRRK2 kinase in Parkinson's disease. [PMID:35147886] | ["Kumar Sachin", "Behl Tapan", "Sehgal A | Environmental science and poll | 2022 | 0 |
| Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease. [PMID:35521944] | Wang S, Unnithan S, Bryant N | Mov Disord | 2022 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Neurodegeneration and Inflammation-An Interesting Interplay in Parkinson's Disea [PMID:33182554] | Marogianni C, Sokratous M, Dardiotis E, | International journal of molec | 2020 | 0 |
| Rab GTPases as Physiological Substrates of LRRK2 Kinase. [PMID:31138985] | Seol W, Nam D, Son I | Exp Neurobiol | 2019 | 0 |
| Multiple Sclerosis Pathology. [PMID:29358320] | Lassmann H | Cold Spring Harbor perspective | 2018 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KINASE ACTIVITY in their description or question text
No additional research found