gene

LRRK2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LRRK2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2480Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

Summary

A gene referenced in 1 knowledge graph relationship. Key connections: inhibits GCase_trafficking (mechanism).

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🧬 Gene Info

Gene Symbol	LRRK2
Full Name	LRRK2 (Leucine-Rich Repeat Kinase 2)
Chromosome	12q12
Protein Type	Protein
Amino Acids	2527 aa
Pathways	MAPK
UniProt ID	Search UniProt
GeneCards	LRRK2
Human Protein Atlas	LRRK2
Variant effect prediction	Predicts functional impact of genetic variants across species
Protein design	Generates novel protein sequences with desired properties
Regulatory element prediction	Identifies enhancers, promoters, and other regulatory sequences
Cross-species transfer	Leverages evolutionary conservation for better predictions
Multi-modal	Handles DNA, RNA, and protein sequences in same model
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Amyotrophic Lateral Sclerosis
Known Drugs/Compounds	RAPAMYCIN, levodopa, Cigarette Smoking, MLi-2, PF-06447475, Environmental Toxicants
Interactions	ATG16L1, RB1CC1, GABARAP, ERN1, STAT3, IFNG
KG Connections	2480 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🧬 3D Structure: LRRK2 — PDB 6VP6 Click to expand

Experimental structure from RCSB PDB | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Arc Institute Evo (Genomic Foundation Model)

ai_tool · 0 words

→

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

→

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

therapeutic · 15567 words

→

Pathway Diagram

graph TD
    LRRK2["LRRK2"] -->|"causes"| PD["PD"]
    LRRK2["LRRK2"] -->|"associated"| Parkinson_s_disease["Parkinson's disease"]
    LRRK2["LRRK2"] -->|"regulates"| SNCA["SNCA"]
    LRRK2["LRRK2"] -->|"causes"| Parkinson_s_disease_1["Parkinson's disease"]
    LRRK2["LRRK2"] -.->|"inhibits"| Parkinson["Parkinson"]
    LRRK2["LRRK2"] -->|"implicated in"| Parkinson_2["Parkinson"]
    GABARAP["GABARAP"] -->|"binds"| LRRK2["LRRK2"]
    STING["STING"] -->|"activates"| LRRK2["LRRK2"]
    CASM_pathway["CASM pathway"] -->|"activates"| LRRK2["LRRK2"]
    GABARAP_3["GABARAP"] -->|"regulates"| LRRK2["LRRK2"]
    style LRRK2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (1640)

Target	Relation	Type	Str
Parkinson	associated_with	disease	1.00
Parkinson	causes	disease	1.00
PARKINSON	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
PARKIN	associated_with	gene	0.98
Mitochondrial Protection	inhibits	process	0.95
Parkinson Disease	risk_factor_for	disease	0.95
Macroautophagy	regulates	process	0.95
Autophagy Process	regulates	process	0.95
Parkinson Disease	causes	disease	0.95
RAB	interacts_with	protein	0.95
Familial Parkinson'S Disease	associated_with	disease	0.95
Parkinson	therapeutic_target	disease	0.95
Als	associated_with	disease	0.95
Parkinson's Disease	risk_factor_for	disease	0.95
Parkinson's Disease	causes	disease	0.95
Parkinson's Disease	contributes_to	disease	0.95
Parkinson'S Disease	therapeutic_target	disease	0.95
Parkinson'S Disease	causes	disease	0.95
Rab GTPases	phosphorylates	protein	0.92
NRF2	regulates	protein	0.90
Type I Interferon Signaling	modulates	pathway	0.90
NFE2L2	inhibits	gene	0.90
RAB GTPASES	phosphorylates	protein	0.90
RAB PROTEINS	targets	protein	0.90
Chaperone-Mediated Autophagy	modulates	pathway	0.90
Crohn's Disease	risk_factor_for	disease	0.90
Paneth Cell Dysfunction	causes	phenotype	0.90
RAB8A	phosphorylates	protein	0.90
Autophagy-Lysosomal Pathway	regulates	pathway	0.90
Kinase Activation	involved_in	mechanism	0.90
Autophagy Pathway	involved_in	pathway	0.90
autophosphorylation	upregulates	process	0.90
Serine 1292 Autophosphorylation	phosphorylates	biomarker	0.90
α-Synuclein Oligomer Accumulation	associated_with	process	0.90
Lysosomal stress	associated_with	process	0.90
Monocytes	expressed_in	cell_type	0.90
PINK1/parkin-mediated mitophagy	inhibits	pathway	0.90
Sporadic Parkinson'S Disease	implicated_in	disease	0.90
PARKINSON DISEASE	associated_with	disease	0.90
Parkinson's disease	activates	disease	0.90
Parkinson's disease	regulates	disease	0.90
oxidative stress response	participates_in	pathway	0.90
MEK	activates	protein	0.90
Α-SYNUCLEIN	associated_with	protein	0.90
PARKINSON	risk_factor_for	disease	0.90
PARKINSON	therapeutic_target	gene	0.90
Endolysosomal Dysfunction	causes	process	0.88
Dysfunctional Alternative Polyadenylation	associated_with	process	0.88
PARKINSON'S DISEASE	risk_factor_for	disease	0.88

Incoming (840)

Source	Relation	Type	Str
RAB29	recruits	protein	1.00
RAB29	operates in a common pathway with	protein	1.00
RAB29	reduces endogenous	protein	1.00
PARKINSON'S DISEASE	associated_with	gene	1.00
GABARAP	binds	gene	0.95
BIIB094	targets	drug	0.95
LRRK2 Inhibitors	inhibits	drug	0.95
G2019S	associated_with	biomarker	0.95
LRRK2 kinase inhibitors	inhibits	drug	0.95
STING	activates	protein	0.90
CASM pathway	activates	pathway	0.90
RAB29	regulates	protein	0.90
MLi-2	inhibits	drug	0.90
PF-06447475	inhibits	drug	0.90
RAB	activates	protein	0.90
INTERFERON GAMMA	upregulates	protein	0.90
Alternative Polyadenylation	modulates	process	0.90
PARKINSON'S DISEASE	therapeutic_target	gene	0.90
ALZHEIMER'S DISEASE	associated_with	disease	0.88
PPM1H	inhibits	protein	0.88
Endolysosomal Dysfunction	activates	process	0.85
VPS35	modulates	protein	0.85
CRISPR-Cas9	targets	process	0.85
Oxidative Stress	activates	process	0.85
PIKFYVE	regulates	protein	0.85
GABARAP	regulates	protein	0.80
lysosome damage	activates	phenotype	0.80
EEF2	phosphorylates	gene	0.80
Environmental Toxicants	activates	compound	0.80
Chaperone Network	regulates	pathway	0.80
GCASE	interacts_with	protein	0.80
MIRO1	interacts_with	protein	0.80
PINK1	associated_with	gene	0.80
NEURODEGENERATION	associated_with	gene	0.80
Cigarette Smoking	activates	compound	0.75
PINK1	therapeutic_target	gene	0.70
PPAR	activates	gene	0.70
NRF2	activates	gene	0.70
YWHAE	regulates	protein	0.70
genetic variants	regulates	compound	0.70
ATP13A2	interacts_with	gene	0.70
DNAJC6	interacts_with	gene	0.70
FBXO7	interacts_with	gene	0.70
GBA1	targets	gene	0.70
RAB GTPases	interacts_with	protein	0.70
LRRK2 inhibitors	inhibits	drug	0.70
GENES	associated_with	gene	0.70
PARKINSON'S DISEASE	activates	gene	0.70
INFLAMMATION	activates	gene	0.70
PARKINSON	activates	gene	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

SEA-AD Gene Expression Profiling — Allen Brain Cell Atlas

neurodegeneration | 2026-04-02 | 5 hypotheses Top: 0.519

Digital biomarkers and AI-driven early detection of neurodegeneration

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.605

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

LRRK2

Understanding Entity Pages

Summary

Wiki Pages (21)

Arc Institute Evo (Genomic Foundation Model)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

AAV Gene Therapy for Neurodevelopmental Epilepsy — Competitive Landscape & Delivery Alternatives

Novel Therapy Index

Parkinson's Disease

Atypical Parkinsonism

Alpha-Synuclein Pathology

PD Combination Therapy Matrix

Corticobasal Degeneration (CBD)

Therapeutics

NPM1 Gene

neuroinflammation

PD Cure Roadmap

Mitochondrial Quality Control

GSK-3β in Neurodegeneration

Mitochondrial Dysfunction in Parkinson's Disease

Synucleinopathy Mechanism

Autophagy Mechanisms

Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Mitophagy Pathway in Neurodegeneration

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases