Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KINESIN1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | KINESIN1 |
| Function | is a microtubule-based motor protein that transports cargo along axonal and dendritic pathways. |
| Amino Acids | 963 aa |
| GeneCards | KINESIN1 |
| Human Protein Atlas | KINESIN1 |
| Motor domain (head) | Located at the N-terminus, contains microtubule binding site and ATPase activity |
| Coiled-coil stalk | Mediates dimerization and cargo binding |
| Tail domain | Binds to cargo adaptors and regulates motor activity |
| Light chain subunit | Associates with heavy chain for cargo recognition |
| Synaptic components | Transports synaptic vesicles, vesicle precursors, and neurotransmitter receptors |
| Mitochondrial trafficking | Mediates distribution of mitochondria along axons [@diefenbacher2020] |
| Protein complexes | Carries signaling molecules, kinases, and transcription factors |
| Membrane organelles | Moves endosomes, Golgi-derived vesicles, and lysosomes |
| Synaptogenesis | Delivers synaptic proteins to developing synapses |
| Synaptic plasticity | Maintains synaptic vesicle pools and receptor distribution |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KINESIN1["KINESIN1"]
neurodegeneration["neurodegeneration"]
KINESIN1 -->|"implicated_in"| neurodegeneration
style KINESIN1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning KINESIN1 in their description or question text
No additional research found