gene

klk6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about klk6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2Connections

0Hypotheses

0Analyses

1Outgoing

1Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	KLK6
Full Name	Kallikrein Related Peptidase 6
Chromosome	19q13.33
Protein Type	Protease
Function	KLK6 (Kallikrein Related Peptidase 6) encodes a trypsin-like serine protease that was originally discovered in the brain and has since been implicated in multiple physiological and pathological proces
Primary Expression	Brain, spinal cord, immune cells
Molecular Weight	27 kDa
Pathways	MAPK, mapk, MAPK pathway, PI3K
UniProt ID	[Q92876](https://www.uniprot.org/uniprot/Q92876)
GeneCards	KLK6
Human Protein Atlas	KLK6
Proteolytic activity	Cleaves various substrates including extracellular matrix proteins, cytokines, and disease-related proteins
Extracellular matrix remodeling	Degrades components of the extracellular matrix including fibronectin, laminin, and collagen
Protein processing	Processes amyloid precursor protein (APP) and other proteins relevant to neurodegeneration
Cytokine activation	Activates pro-inflammatory cytokines and modulates neuroinflammation
Associated Diseases	neurodegeneration through protein cleavage
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

klk6

gene · 1167 words

→

Pathway Diagram

graph TD
    A["Regulatory elements"] --> B["klk6 gene"]
    B --> C["mRNA transcript"]
    C --> D["Protein product"]
    D --> E["Cellular function"]
    E --> F["Disease relevance"]
    B --> G["Variant effects"]
    G --> F
    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    class B gene
    class D protein

Outgoing (1)

Target	Relation	Type	Str
benchmark_ot_ad_answer_key:KLK6	data_in	dataset_row	0.00

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:KLK6	data_in	dataset_row	0.00

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity