| Gene Symbol | KLK6 |
| Full Name | Kallikrein Related Peptidase 6 |
| Chromosome | 19q13.33 |
| Protein Type | Protease |
| Function | KLK6 (Kallikrein Related Peptidase 6) encodes a trypsin-like serine protease that was originally discovered in the brain and has since been implicated in multiple physiological and pathological proces |
| Primary Expression | Brain, spinal cord, immune cells |
| Molecular Weight | 27 kDa |
| Pathways | MAPK, mapk, MAPK pathway, PI3K |
| UniProt ID | [Q92876](https://www.uniprot.org/uniprot/Q92876) |
| GeneCards | KLK6 |
| Human Protein Atlas | KLK6 |
| Proteolytic activity | Cleaves various substrates including extracellular matrix proteins, cytokines, and disease-related proteins |
| Extracellular matrix remodeling | Degrades components of the extracellular matrix including fibronectin, laminin, and collagen |
| Protein processing | Processes amyloid precursor protein (APP) and other proteins relevant to neurodegeneration |
| Cytokine activation | Activates pro-inflammatory cytokines and modulates neuroinflammation |
| Associated Diseases | neurodegeneration through protein cleavage |
| Databases | GeneCardsNCBI GeneHPASTRING |
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