protein

KV33

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about KV33: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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🔬 Protein Info

Gene Symbol	KV33
Protein Type	Channel
Function	is an important component in the neurobiology of neurodegenerative diseases.
Subcellular Localization	</th><td>Plasma membrane</td></tr>
Molecular Weight	95 kDa
GeneCards	KV33
Human Protein Atlas	KV33
Voltage sensor domain	S1-S4
Pore domain	S5-S6
Voltage sensor	S4 helix with positively charged residues
Selective filter	KVFYF signature sequence
Activation voltage	Depolarized potentials (+10 to +50 mV)
Deactivation	Very fast (1-3 ms)
Current density	High in fast-spiking neurons
Modulation	Phosphorylation, oxidative stress
Associated Diseases	neurodegeneration
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Kv3.3 Potassium Channel

protein · 640 words

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Pathway Diagram

graph TD
    KV33["KV33"]
    neurodegeneration["neurodegeneration"]
    KV33 -->|"implicated_in"| neurodegeneration
    style KV33 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning KV33 in their description or question text

No additional research found