Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LAPTM4A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | LAPTM4A |
| Full Name | Lysosomal Associated Transmembrane Protein 4 Alpha |
| Chromosome | 2p23.3 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues including the brain, where it supports neuronal survival and function |
| Subcellular Localization | Primarily lysosomal membranes |
| Amino Acids | 224 aa |
| Pathways | mTOR, mtor |
| UniProt ID | [Q9Y3Q5](https://www.uniprot.org/uniprot/Q9Y3Q5) |
| Ensembl ID | ENSG00000137714 |
| GeneCards | LAPTM4A |
| Human Protein Atlas | LAPTM4A |
| Lysosomal membrane integration | Contains multiple transmembrane domains that anchor it in the lysosomal membrane |
| Membrane protein interactions | Interacts with other lysosomal membrane proteins |
| Lysosomal pH maintenance | Contributes to lysosomal acidification and function |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
LAPTM4A["LAPTM4A"]
neurodegeneration["neurodegeneration"]
LAPTM4A -->|"implicated_in"| neurodegeneration
style LAPTM4A fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
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Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
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Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
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| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
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Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning LAPTM4A in their description or question text
No additional research found